Abstract
Prolactin (PRL) is secreted in a pulsatile manner by lactotroph cells in the anterior pituitary gland and displays a circadian rhythm as well as increases in response to stress, sexual intercourse, breast stimulation, and suckling. We propose a mathematical model of prolactin secretion which is mainly controlled by the inhibiting effect of dopamine (DA) and the stimulating effect of thyrotopin releasing hormone (TRH). By applying the singular perturbation technique, the conditions are derived under which our model exhibits a periodic solution corresponding to the normal secretory pattern of PRL which has been observed as a series of daily pulses, occurring every 2–3 hours. Numerical investigations also show that chaotic time series is admitted by our model which resembles irregular patterns observed in PRL concentration profiles of patients with microprolactinoma and macroprolactinoma. Explaining the conditions that delineate varying dynamic behavior in this nonlinear system in terms of the removal rates of the three state variables, the removal rate d 1 of TRH seems to play the most important role in identifying different physiological conditions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
