Abstract
Corneal endothelial cell loss is one of the possible complications associated with phakic iris-fixated intraocular lens (PIOL) implantation. We postulate that this might be connected to the alteration of corneal metabolism secondary to the lens implantation. A mathematical model of transport and consumption/production of metabolic species in the cornea is proposed, coupled with a model of aqueous flow and transport of metabolic species in the anterior chamber. Results are presented both for open and closed eyelids. We showed that, in the presence of a PIOL, glucose availability at the corneal endothelium decreases significantly during sleeping. Implantation of a PIOL significantly affects nutrient transport processes to the corneal endothelium especially during sleep. It must still be verified whether this finding has a clinical relevance.
Highlights
In the presence of a phakic iris-fixated intraocular lens (PIOL), glucose availability at the corneal endothelium decreases significantly during sleeping
PIOLs are surgically implanted in the anterior chamber of the eye and fixated to the iris by haptics
A decrease in corneal endothelial cell density has been observed after PIOL implantation,[1,2] this finding is still under debate and some authors have not observed evidence of it.[3]
Summary
The aim of the present work was to explore this hypothesis
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