Abstract
The dynamics of both the General Factor of Personality and the personality biological indicators, as a consequence of a stimulus, can be described with a short‐term dynamic model (the response model). The invariance of the response model at both levels of description (psychological and biological) leads to deduce the bridge model with which psychological and biological levels of description can be related. The bridge model is the key tool to deal with the body–mind problem. An application case is presented setting up an experimental design with two subjects. The General Factor of Personality, c‐fos and glutamate dynamics are evaluated as a consequence of a methylphenidate dose intake. The response and bridge models are validated with the outcomes of the application case. Copyright © 2013 John Wiley & Sons, Ltd.
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