Abstract
AbstractIsocyanide‐based multicomponent reactions (I‐MCRs) represent a milestone in combinatorial chemistry. Recently, efforts have been made to include I‐MCRs in tandem or sequential pathways to synthesise more complex molecules, and the bicyclo[2.2.1]heptene (norbornene) moiety has been demonstrated to be a very versatile scaffold when employed to broaden the scope of the multicomponent approach, making it perfectly suited for diversity‐oriented synthesis. In addition to this, the (hetero)norbornane/norbornene scaffold has been shown to influence the stereocontrol of the multicomponent condensation strongly, in some instances making this synthetic approach completely stereoselective. Finally, because of their intrinsic complexity, the resulting molecular entities can find many applications, from biology to polymer science. This review summarises the results obtained in this emerging field.
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