Abstract
El-Omar et al. (1) reported that interleukin (IL)-1 gene cluster variants that enhance the production of IL-1β (a powerful inhibitor of gastric acid secretion) increase the risk of gastric cancer in Helicobacter pylori (HP)-infected patients. IL-1β production is down-regulated by mannose-binding lectin (MBL) (2), an acute-phase glycoprotein that has a high affinity for gram-negative lipopolysaccharide and exerts immunological activity (3)(4). Variants in the promoter, the 5′UTR, and exon 1 of the MBL2 gene reduce the synthesis and activity of MBL (5). To assess the relationships between MBL2 gene variants and HP-related gastric cancer, we analyzed the whole coding region and the 5′UTR of the MBL2 gene in DNA extracted (QIAamp, Qiagen) from neoplastic cells embedded in paraffin sections (used for histological diagnosis) from 145 unrelated patients (90 males) affected by noncardia gastric cancer. Eighty-seven (60.0%) had intestinal-type; 47 (32.4%), diffuse-type; and 11 (7.6%), mixed-type adenocarcinoma. All patients had HP-positive serology. For 75 patients, we …
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