Abstract
Nitric oxide (NO) is an important gas signaling molecule, is present in the alveoli in correlation with the extent of idiopathic pulmonary fibrosis (IPF) patients. In this work, a high-order multiphoton fluorescent probe FS-MnCl2 is designed and synthesized for detecting NO level in mice model of IPF. FS-MnCl2 has the advantage of low detection limit (11 nM) and resistance to photobleaching in vitro. The three-photon absorption cross section is greatly enhanced after FS-MnCl2 recognizes NO. Moreover, the fluorescence intensity of FS-MnCl2-NO is stronger than that of FS-MnCl2 in the presence of RNA. Biological applications suggest that FS-MnCl2 can monitor changes in NO levels in living cells and IPF mice. This work provides a new strategy for reasonably designing Mn(Ⅱ) complex that can respond to NO for predicting IPF at an early stage.
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