A mammary adenocarcinoma murine model suitable for the study of cancer immunoediting

Lucas Pagura,Ricardo José Di Masso,Olga Graciela Scharovsky,María José Rico,Juan Manuel Cáceres,Mariano Federico Zacarías-Fluck,Albertina Cardinale,Viviana Rosa Rozados

doi:10.1186/1423-0127-21-52

Abstract

BackgroundCancer immunoediting is a dynamic process composed of three phases: elimination (EL), equilibrium (EQ) and escape (ES) that encompasses the potential host-protective and tumor-sculpting functions of the immune system throughout tumor development. Animal models are useful tools for studying diseases such as cancer. The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi− and CBi/L inbred mice lines.ResultsThe mammary adenocarcinoma M-406 developed spontaneously in a CBi mouse. CBi/L and CBi− mice were artificially selected for body conformation from CBi. When CBi mice are s.c. challenged with M-406, tumor growths exponentially in 100% of animals, while in CBi− the tumor growths briefly and then begins a rejection process in 100% of the animals. In CBi/L the growth of the tumor shows the three phases: 51.6% in ES, 18.5% in EQ and 29.8% in EL.ConclusionsThe results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi− and CBi/L, is a good murine model to study the process of tumor immunoediting.

Highlights

IntroductionIntroduction to Quantitative GeneticsNew York: Longmans; 1989. 10. Hinrichsen L, Di Masso RJ, Vasconi MD, Giudici C: Animal Models Suitable toStudy Complex Polygenic Processes
Introduction to Quantitative GeneticsNew York: Longmans; 1989. 10
It is currently accepted that the immune system can protect against tumor development but it is capable of stimulating tumor growth

Summary

Introduction

Introduction to Quantitative GeneticsNew York: Longmans; 1989. 10. Hinrichsen L, Di Masso RJ, Vasconi MD, Giudici C: Animal Models Suitable toStudy Complex Polygenic Processes. Cancer immunoediting is a dynamic process composed of three phases: elimination (EL), equilibrium (EQ) and escape (ES) that encompasses the potential host-protective and tumor-sculpting functions of the immune system throughout tumor development. The immune system can promote tumor progression through chronic inflammation, immunoselection of poorly immunogenic variants and by suppressing antitumor immunity These dual host-protective and tumor-promoting actions of immunity are referred to as cancer immunoediting [12]. The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi FS, CBi− FS and CBi/L FS inbred mice lines, as a model for studying the process of cancer immunoediting

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Discussion

Conclusion