Abstract
Background: Anti-Ma2 antibody associated paraneoplastic syndrome (PNS) usually presents as limbic encephalitis in the context of testicular tumors. We report a rare case of anti-Ma2 positive PNS with deviation from the classic scenario, thus expanding the phenotype of anti-ma2 associated PNS. Case presentation: This is a 53-year-old male who presented with what was later diagnosed as anti-Ma2 antibody positive cerebellar ataxia. Further workup revealed retroperitoneal lymphadenopathy which, using biopsy, was identified as metastatic clear cell renal cell carcinoma (RCC). However, imaging did not reveal a primary renal lesion. Conclusion: Physicians should be aware of non-classic presentations of paraneoplastic syndromes, especially given that they commonly precede and point towards an underlying, many times undiagnosed, malignancy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
