A Malaria Vaccine: Promising Results, but Not There Yet

Abstract

Research Article| March 01 2012 A Malaria Vaccine: Promising Results, but Not There Yet AAP Grand Rounds (2012) 27 (3): 26. https://doi.org/10.1542/gr.27-3-26 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation A Malaria Vaccine: Promising Results, but Not There Yet. AAP Grand Rounds March 2012; 27 (3): 26. https://doi.org/10.1542/gr.27-3-26 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search nav search search input Search input auto suggest search filter All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: malaria, malaria vaccines, vaccines Source: The RTS,S Clinical Trials Partnership. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med. 2011; 365(20): 1863– 1875; doi: https://doi.org/10.1056/NEJMoa1102287 An international group of researchers performed this double-blind, randomized trial involving eleven centers in seven African countries to determine the efficacy, safety, and immunogenicity of RTS,S/AS01, a candidate malaria vaccine in infants and young children. The vaccine is a recombinant vaccine in which the malaria protein is fused to the hepatitis B surface antigen. After enrollment in the study, children were divided into two age groups: 6 to 12 weeks (6,537 participants) and 5 to 17 months (8,923 participants). Children in each group were then randomly assigned to three doses of the vaccine at one-month intervals; a control group received a non-malaria vaccine. In the 6 to 12 weeks age group, the control... You do not currently have access to this content.