Abstract
In the field of free thyroid hormone testing, methods based on equilibrium dialysis (ED) or ultrafiltration (UF) of serum, before direct measurement of the hormone concentration in the dialysate or ultrafiltrate, are accepted to be gold standards(1). These measurement procedures, however, physically isolate the free from the protein-bound hormone fractions and have been considered too technically demanding, inconvenient, and relatively expensive for routine clinical laboratory use(2)(3). Typically, such methods are better suited for use in reference laboratories(4). In this issue of Clinical Chemistry , Yue et al. report on the application of an ED isotope dilution–liquid chromatography/tandem mass spectrometric (ID–LC-MS/MS) procedure developed in-house …
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