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Abstract
We investigate changes in brain function before and after carpal tunnel release. Magnetoencephalography (MEG), during which we recorded somatosensory evoked cortical magnetic fields (SEFs), and a clinical evaluation were performed before surgery and 6 months after. The distance on the vertical axis between the equivalent current dipoles (ECDs) for the first and third digits before surgery was significantly less than after surgery. There were no significant differences in values between the control participant and patients after surgery. In terms of distal motor latency, there was a negative correlation with the distance. The recovery function of the root mean square (RMS) before surgery for the N20m was less suppressed at 10 ms of ISI in patients, compared to controls. There were no significant differences in the RMS values for patients before and after surgery. Our results indicate that treating peripheral nerve lesions, such as in carpal tunnel release, positively modifies brain function.
Highlights
We investigate changes in brain function before and after carpal tunnel release
There were no significant differences in the root mean square (RMS) values for patients before and after surgery (Fig. 3)
A particular strength of MEG is that it allows measurement of the magnetic field of the brain caused by the electrical activity of nerves without being affected by extra-cerebral tissues[18]
Summary
We investigate changes in brain function before and after carpal tunnel release. Magnetoencephalography (MEG), during which we recorded somatosensory evoked cortical magnetic fields (SEFs), and a clinical evaluation were performed before surgery and 6 months after. Brain plasticity changes, which can be adaptive or maladaptive, occur following peripheral and central nerve lesions These changes have been shown in patients with carpal tunnel syndrome (CTS), one of the most common peripheral neuropathies. Dhond et al.[7] have reported that fMRI and MEG results are novel markers of neuroplasticity in CTS and can be used to study central changes that may occur following clinical interventions. Both morphological and functional brain changes have revealed brain plasticity. A reduced second/third interdigit cortical separation distance in the contralateral primary somatosensory cortex is associated with worse symptomatology ( paresthesia), reduced fine motor skill performance, and poorer sensory discrimination accuracy for median nerve innervated digits. We questioned whether the central nervous system responses that had been modified by a peripheral nerve lesion could be remodified by the treatment
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