Abstract
BackgroundIn the past decades, different diseases and viruses, such as Ebola, MERS and COVID-19, impacted the human society and caused huge cost in different fields. With the increasing threat from the new or unknown diseases, the demand of rapid and sensitive assay method is more and more urgent.ResultsIn this work, we developed a magneto-optical biochip based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell magnetic nanoparticles. We performed a proof-of-concept experiment for the detection of the spike glycoprotein S of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The assay was achieved by measuring the magneto-optical Cotton–Mouton effect of the biochip. This magneto-optical biochip can not only be used to detect SARS-CoV-2 but also can be easily modified for other diseases assay.ConclusionThe assay process is simple and the whole testing time takes only 50 min including 3 min for the CM rotation measurement. The detection limit of our method for the spike glycoprotein S of SARS-CoV-2 is estimated as low as 0.27 ng/mL (3.4 pM).Graphic abstract
Highlights
Since the outbreak at the end of 2019, coronavirus disease 2019 (COVID-19) has caused a global pandemic
To be inspired by the COVID-19 pandemic, we developed a biochip for the rapid disease assay based on the magneto-optical (MO) Cotton–Mouton (CM) effect of γ-Fe2O3@Au core/shell magnetic nanoparticles (MNPs)
We performed a proof-of-concept experiment and demonstrated an easy and quick assay method for the in vitro detection of the SARS-CoV-2. This assay method is achieved by using the MO CM effect and a biochip that is based on γ-Fe2O3@Au nanoparticles
Summary
Since the outbreak at the end of 2019, coronavirus disease 2019 (COVID-19) has caused a global pandemic. The health and safety of individuals worldwide have been seriously threatened It was quickly confirmed as a new type of coronavirus and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the. To be inspired by the COVID-19 pandemic, we developed a biochip for the rapid disease assay based on the magneto-optical (MO) Cotton–Mouton (CM) effect of γ-Fe2O3@Au core/shell magnetic nanoparticles (MNPs). Results: In this work, we developed a magneto-optical biochip based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell magnetic nanoparticles. The assay was achieved by measuring the magneto-optical Cotton–Mouton effect of the biochip. This magneto-optical biochip can be used to detect SARS-CoV-2 and can be modified for other diseases assay. The detection limit of our method for the spike glycoprotein S of SARS-CoV-2 is estimated as low as 0.27 ng/mL (3.4 pM)
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