Abstract
Overweight and obesity have been identified as a cause of high risk diseases like diabetes and cancer. Although conventional Intragastric Balloons (IGBs) have become an efficient and less invasive method for overweight and obesity treatment, the use of conventional tools such as catheter or endoscope to insert and remove the IGBs from the patient’s body causes nausea, vomiting, discomfort, and even gastric mucous damage. To eliminate these drawbacks, we develop a novel magnetic soft capsule device with gas-filled balloon inflation. The balloon is made from a thin and biocompatible material that can be inflated to a desired volume using biocompatible effervescent chemicals. In addition, both the outer balloon and inner capsule are designed to be soft and chemical resistance. The soft capsule shell is fabricated using scaffold-solvent approach while the outer balloon utilizes a novel fabrication approach for 3D spherical structure. A prototype of the proposed capsule and balloon is given. Experiments are successfully carried out in stimulated gastric environment and fresh porcine stomach to validate the effectiveness and reliability of the proposed approach.
Highlights
Overweight and obesity are a negative health issue that increase the chance of chronic degenerative diseases such as diabetes, gastrointestinal cancer or even death
In this paper, we develop a new type of magnetic soft capsule endoscope that can control the inflation and deflation of a novel outer Intragastric Balloons (IGBs)
Three main features of the proposed soft capsule that outperform our previous approach include: (i) The whole capsule shells are soft, acid resistant, and biocompatible, (ii) the proposed magnetic soft capsule includes only an inner magnetic mechanism that can be used for both the inflation and deflation of the outer balloon compared to our previous approach where two inner magnetic mechanisms are required for both inflation and deflation phase, and (iii) the outer balloon which is obtained using novel fabrication method is acid resistant, soft, thin, biocompatible, and strong enough to resist the contraction force from the stomach motion
Summary
Overweight and obesity are a negative health issue that increase the chance of chronic degenerative diseases such as diabetes, gastrointestinal cancer or even death. Introduced a smaller capsule size using magnetic actuator with no limitations on the power supply These proposed approaches did not require any endoscopic tools to remove and place the capsule in the stomach, many limitations still exist such as large size, higher risks for the patient, insufficient power supply, rigid capsule shell, complex inflation and deflation mechanism, and not biocompatible and chemical resistant for both balloon and capsule shell. To overcome these limitations, in this paper, we develop a new type of magnetic soft capsule endoscope that can control the inflation and deflation of a novel outer IGB. The new method allows a flexible control of the balloon size and thickness but simple, stable, and low cost
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