Abstract
We previously developed a magnetic probe equipped with a ring-shaped permanent magnet for detecting magnetic nanoparticle tracer accumulating in the sentinel lymph nodes (SLNs). The magnetic probe enables us to identify SLNs objectively, without the risk of radiation exposure, unlike the conventional technique using dye and radioisotope. A technical challenge of the probe is to reduce the tip diameter of magnet to identify smaller SLNs. In this study, we optimized the size of smaller-tip magnet based on numerical analyses using the finite element method and evaluated the expected sensitivity. According to the analysis results, the optimum tip diameter and length of convex-shaped magnet were 16 mm and 12 mm, respectively. The experimental results showed that the sensitivity of the probe with smaller-tip magnet was comparable to the previous one. We successfully developed a smaller tip magnet, maintaining the sensitivity to magnetic nanoparticles. The proposed probe will be capable of identifying the location of SLNs more easily.
Highlights
The sentinel lymph nodes (SLNs) are the lymph nodes which receive the lymphatic flow firstly from a cancer lesion
We developed a magnetic probe equipped with a Hall-effect sensor and ring-shaped permanent magnet, and this probe can be used without cooling medium
The results revealed that the optimum tip diameter and length of the magnet are 16 mm and 12 mm, respectively
Summary
The sentinel lymph nodes (SLNs) are the lymph nodes which receive the lymphatic flow firstly from a cancer lesion. For developing a treatment plan, presence of metastasis in the SLNs is diagnosed by means of a biopsy of SLNs.[1,2] The identification of SLNs is performed using a radioisotope or a dye as a tracer.[2,3,4] the identification of SLNs using dye can be introduced in any hospitals, the procedure depends on a subjective visual inspection. The identification using radioisotope is objective because of the use of a gamma probe. The radioisotope should be used in a dedicated facility which is not available in many hospitals
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
