Abstract
HSP70 gene expression is induced by a wide range of environmental stimuli, including 60-Hz electromagnetic fields. In an earlier report we showed that the induction of HSP70 gene expression by magnetic fields is effected at the level of transcription and is mediated through c-myc protein binding at two nCTCTn sequences at −230 and −160. in the human HSP70 promoter. We report on the identification of a third c-myc binding site (between −158 and −162) that is an important regulator of magnetic field-induced HSP70 expression. We also show that the heat shock element (HSE), lying between −180 and −203, is required for induction of HSP70 gene expression by magnetic fields. The HSE centered at −100 alone is insufficient. J. Cell. Biochem. 77:170–176, 1999. © 1999 Wiley-Liss, Inc.
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