Abstract
A new phenothiazine derivative as lysosome-targeted fluorescent probe with a large blue-shift (128nm) for ClO- detection in a fine ratiometric manner has been designed and synthesized. Probe Lyso-PTB has remarkable fluorescence ratiometric variations (98-fold), low cytotoxicity, rapid response time (50s) and a low detection limit (23nM). In particular, the application of Lyso-PTB for ClO- detection was successfully demonstrated in lysosome and in zebrafish.
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