Abstract
Vacuolar H+-ATPase (V-ATPase) is a glucose-responsive, ATP-driven proton pump that controls the acidity of cellular organelles. Increases in glucose stimulate V-ATPase assembly and activity, and glucose deprivation triggers rapid V-ATPase disassembly and inactivation in yeast. McGuire and Forgac describe the opposite phenomenon in mammalian cells, specifically that V-ATPase assembly and activation increases when glucose is lost, raising new questions about mammalian mechanisms of energy conservation.
Highlights
Vacuolar H؉-ATPase (V-ATPase) is a glucose-responsive, ATP-driven proton pump that controls the acidity of cellular organelles
Glucose is the preferred energy source for most organisms, and cells possess sophisticated mechanisms for sensing and responding to it. One of these mechanisms is the glucose-mediated regulation of vacuolar Hϩ-ATPase (V-ATPase),2 an ATP-driven proton pump that generates pH gradients in the endomembrane system of eukaryotes
McGuire and Forgac [3] show that mammalian V-ATPase responds to glucose deprivation in a novel manner, highlighting fascinating species-specific differences in the ways that organisms respond to energy deficits
Summary
Vacuolar H؉-ATPase (V-ATPase) is a glucose-responsive, ATP-driven proton pump that controls the acidity of cellular organelles. McGuire and Forgac [3] show that mammalian V-ATPase responds to glucose deprivation in a novel manner, highlighting fascinating species-specific differences in the ways that organisms respond to energy deficits. It is believed that this regulated assembly cycle is essential for maintaining energy and pH homeostasis across the cell: V-ATPase
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