A luminescent cyclometalated gold(iii)-avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity.

Johnson Lui-Lui Tsai,Chi-Ming Che,Anna On-Yee Chan

doi:10.1039/c5cc00186b

A luminescent cyclometalated gold(iii)-avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity.

Johnson Lui-Lui Tsai, Chi-Ming Che + Show 1 more

https://doi.org/10.1039/c5cc00186b

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Journal: Chemical Communications	Publication Date: Jan 1, 2015
Citations: 28

Affiliation: State Key Laboratory of Synthetic Chemistry, University of Hong Kong, Institute of Molecular Functional Materials, Department of Health

#Avidin Conjugate #PBS Solution + Show 8 more

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Abstract

Here we describe a luminescent cyclometalated Au(iii)-avidin conjugate that exhibits a 520 nm emission with a lifetime of 1.8 μs in PBS solution in open air. The conjugate stains proteins and DNA and can inhibit cancer cell proliferation.

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