A Low-temperature Manganese Chloride Tetrahydrate Improves the Image Quality of Magnetic Resonance Cholangiopancreatography

Abstract

Manganese chloride tetrahydrate (MCT) is one of the oral negative contrast agents which is indispensable for imaging of magnetic resonance cholangiopancreatography (MRCP). In this study, improvement of the image quality of MRCP by using low-temperature MCT is verified. All MR imagings were performed using 1.5 T scanner. The T(1) and T(2) values of the different temperature MCTs were measured in the phantom study. Different concentrations of MCT-doped water (30%, 50%, 70%, and 90%) were measured at several temperature conditions (10°C, 15°C, 23°C, 35°C, and 40°C). As a result, the T(1) and T(2) values became larger with a temperature rise. It was more remarkable in low-concentration MCT. Then, 17 healthy subjects were scanned two times with different temperatures of MCT. The MCT of the normal temperature (23°C) and low temperature (10°C) were taken at consecutive 2 days. The contrast between the stomach and the spleen were significantly higher in 2D half Fourier acquisition single shot turbo spin echo (HASTE) images by use of the low-temperature MCT. The contrast between the common bile duct and the adjacent background were significantly higher in the source images of 3D MRCP by use of the low temperature MCT. In addition, 76% of subjects answered in the questionnaire that the low temperature MCT is easier to drink. The low temperature MCT improves the image quality of MRCP and contributes to performing noninvasive examination.