Abstract
The objective of this study was to examine the influence of dietary protein levels on development of hyperphagia and obesity in rats that had been given surgical knife cuts between the ventromedial and lateral areas of the hypothalamus. Under normal conditions, rats with this type of surgery exhibit hyperphagia and become obese when given unlimited access to dietary energy. Earlier studies indicated impaired adaptive diet-induced thermogenesis in response to excess energy intake in this animal model of obesity. Because low protein diets can also stimulate diet-induced thermogenesis, we conducted four experiments which examined how diets containing different levels of protein affect development of hyperphagia and obesity in female rats given bilateral, parasagittal wire knife cuts between the ventromedial and lateral areas of the hypothalamus. For 28 d, knife-cut and sham-operated rats were given unlimited or restricted (179 or 180 kJ/d) access to diets containing protein at 5, 10 or 20% of total metabolizable energy. Knife-cut rats with unlimited access to 10 or 20% protein diets became obese, gaining 2–3 times more weight and 3–6 times more carcass energy while consuming 55–89% more energy than sham-operated rats. In contrast, energy consumed and gained by knife-cut rats with unlimited access to a 5% protein diet was similar to that of rats given sham surgery. Results indicate that a low protein diet effectively blocks development of hyperphagia and obesity in rats with surgical knife cuts between the ventromedial and lateral regions of the hypothalamus.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.