Abstract
SummaryLow power/area cytomorphic chips may be interfaced and ultimately implanted in the human body for cell‐sensing and cell‐control applications of the future. In such electronic platforms, it is crucial to accurately mimic the biological timescales and operate in real time. This paper proposes a methodology where slow nonlinear dynamical systems describing the behaviour of naturally encountered biological systems can be efficiently realised in hardware. To this end, as a case study, a low power and efficient digital Application‐Specific Integrated Circuit capable of emulating slow intracellular calcium dynamics with timescales reaching to seconds has been fabricated in the commercially available AMS 0.35 μm technology and compared with its analog counterpart. The fabricated chip occupies an area of 1.5 mm2 (excluding the area of the pads) and consumes 18.93 nW for each calcium unit from a power supply of 3.3 V. The presented cytomimetic topology follows closely the behaviour of its biological counterpart, exhibiting similar time‐domain calcium ions dynamics. Results show that the implemented design has the potential to speed up large–scale simulations of slow intracellular dynamics by sharing cellular units in real time.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Circuit Theory and Applications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
