Abstract

Malnutrition is a factor for increased morbidity and mortality in chronic dialysis patients. Bioelectrical impedance analysis is a useful tool for assessing body composition. An additional parameter, the phase angle (arctangence of the reactance to resistance ratio), provides an index of body cell mass content and cell membrane integrity. We evaluated the clinical significance of a low phase angle on nutritional status and mortality in chronic dialysis patients. A total of 285 subjects entered a prospective longitudinal observational study (mean age: 62±14 years; 41% females; 37% black; 43% diabetic; median follow up: 18 months). Patients were divided into three groups by phase angle tertiles. Values are expressed as mean ± SD. Patients with lower phase angle values had lower body weight, BMI, fat free mass, body cell mass, and serum albumin than those in the higher tertile (P < 0.0001). In addition, mortality rates were significantly lower (P=0.050) in 3rd tertile patients when compared to the combined 1st and 2nd tertiles. In conclusion: the phase angle is a useful tool for identifying dialysis patients at high risk for malnutrition and increased mortality.Table

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