Abstract
The principles and historical development of ion-exchange chromatography are discussed briefly. Modern ion chromatography includes ion-exchange, ion-pair, ion-exclusion and the chromatography of ion—organic complexes. Each is explained briefly. The major detection systems for ion chromatography are outlined: conductivity (suppressed and non-suppressed), direct and indirect spectrophotometry, spectrophotometry with a post-column reactor, electrochemical, and differential refractometry. The question of isocratic vs. gradient elution is examined briefly. Recent studies on the selectivity of ion-exchange resins are presented. Several examples are given of recent separation methods from the author's laboratory. These include the separation of weak acids by ion-exclusion chromatography, the use of additional ion-exchange columns to enhance the detection of carbonic acid by conductivity, and the determination of metal cations by complexation and subsequent chromatographic separation.
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