A longitudinal study of electrogastrography in normal neonates

Abstract

Gastric motility is partly regulated by an inherent electric control activity (ECA). Electrogastrography (EGG) measures gastric ECA through cutaneous electrodes. Little is known about EGG in neonates. A slow wave frequency of 3 cycles per minute (cpm) accounts for 85% to 100% of gastric ECA in normal adults and children. However, the authors have shown previously a lower percentage of 3 cpm activity in neonates. Abnormal EGG patterns (tachygastria and bradygastria) have been described in adults and children with gastric motility disorders. In neonates, especially premature infants, disorders of gastrointestinal motility are common, especially after gastrointestinal operations. It is necessary to characterise normal ECA before the pathophysiology of these disorders can be studied. The aim of this study was to investigate the pattern of ECA in the developing neonate. Nine healthy neonates born at 34 weeks' gestation were studied using Synectics EGG sampling at 4 Hz. Each subject underwent 4 hourly EGG recordings at fortnightly intervals from birth until age 8 weeks, and then every 2 months until age 2 years. The paired sample t test (95% Confidence Interval [CI]) was used to compare recordings. Between birth and age 2 years, 3 cpm activity increased from 38% to 57% of recorded time. The mean percentage recorded time of tachygastria decreased from 47% to 35%, and bradygastria decreased from 15% to 8%. Statistically significant differences were seen between birth, 6 months, and 2 years of age. The pattern of ECA in the normal neonatal stomach differs from that seen in adult studies. Tachygastria and bradygastria are seen more frequently, with fewer periods of 3 cpm. There is an increase in the percentage of 3 cpm activity over time, with statistically significant differences from the ECA pattern at birth first seen at the age of 6 months. The authors suggest that neonatal ECA undergoes a maturation process and that larger longitudinal and normal range studies are required to investigate this phenomenon.