A longitudinal assessment of health-related quality of life in patients undergoing active surveillance for early prostate cancer in Japan (PRIAS-JAPAN).

Abstract

56 Background: There are few reports of the health-related quality of life (HRQOL) of Asian prostate cancer patients who choice active surveillance. We evaluate HRQOL in participants of the Prostate Cancer Research International Active Surveillance study (PRIAS-JAPAN). Methods: The participants’ general HRQOL was assessed longitudinally using the Short Form 8 Health Survey (SF-8) at enrollment and annually thereafter until discontinuation of active surveillance (AS). We compared the quality of life and baseline score of participants with that of the general population (Norm-based scoring [NBS] 50) using paired t-test and the mixed models. Age-adjusted logistic regression was applied to the 3-year AS remaining rate. Results: The SF-8 questionnaire was administered to 570 patients (median age, 68 [range, 45–87] years). We evaluated 484, 328, 140, 84, and 68 patients at enrollment and 1, 2, 3, and 4 years thereafter. At enrollment, the mean physical component summary (PCS) score and all subscales revealed better HRQOL than NBS. No significant difference was noted in mental component summary (MCS) compared to NBS at enrollment. However, MCS at 1, 2, and 4 years was higher than the NBS. PCS slightly diminished in 4 years, whereas MCS at all time points showed no change. Age-adjusted logistic regression showed an OR of 1.66 (95% CI: 1.047–2.632, P = 0.0313) on 3-year AS remaining rate in favor of patients with above median MCS at enrollment. Conclusions: Men who were enrolled into the PRIAS-JAPAN study had better HRQOL than that of NBS. PCS decreased but MCS did not. The AS remaining rate was influenced by baseline MCS.