Abstract
SummaryThe antihypertensive effect of indapamide (2.5 mg daily for periods of up to 10 months) was investigated in 20 hypertensive patients, 60% of whom achieved excellent blood pressure control, and a further 30% were moderately well controlled. Indapamide treatment had no significant effect on the status of either the exchangeable potassium and sodium pools, assessed by an isotope dilution technique, suggesting that the antihypertensive activity of the compound cannot be solely attributed to its saluretic diuretic properties. The mechanism of action of indapamide in the light of these results is suggested to be a combination of the initial saluretic diuretic properties and a direct action on the arterial wall.
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