A little bit of LOGIC goes a long way: Multidisciplinary management of LOGIC Syndrome‐associated oral manifestations

Abstract

AbstractLOGIC syndrome (laryngeal and ocular granulation tissues in children from the Indian subcontinent), also known as Laryngo‐onycho‐cutaneous (LOC) syndrome, is a rare, autosomal recessive condition that is a subtype of junctional epidermolysis bullosa (JEB), primarily occurring in individuals of Punjabi ancestry. First observed by Shabbir et al in 1986, it has since been discovered that the syndrome is a result of autosomal recessive mutations in the LAMA3 gene. The clinical manifestations of the syndrome can be life threatening and are characterised by excessive granulation tissue deposition on the skin and mucous membranes including laryngeal, ocular and oral sites. Oral manifestations can drastically affect the quality of life. We present a case of LOGIC syndrome to highlight the importance of clinicians understanding the oral manifestations of the syndrome and implementing a multidisciplinary approach with good communication across specialities, including pathologists.