Abstract
n the present publication, Kilic et al. utilized a rat corneal angiogenesis assay (CAA) to evaluate the effects of various I gamma knife radiosurgery doses on angiogenesis due to corneal grade 1 to 3 meningioma implants. Twenty-four CAAs for each grade were divided into 4 groups of 6, and each group received 0, 14, 18, and 22 Gy, respectively. Vessel numbers were counted on days 5, 10, 15, and 20 after implantation day 0, with the radiosurgery treatment date specified as day 1. Grade 1 meningioma-induced vessel growth was maximally inhibited by 18 Gy and to a lesser degree by 22 Gy, whereas the growth of the grade 2 assays was inhibited by 22 Gy alone. The grade 3 vasculature had no response to any dose.
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