Abstract
Spleen and thymus cells from Swiss Webster ICR mice were separated into enriched subpopulations using anti-Lyt-1.2 and anti-Lyt-2.2, and tested for lymphokine production in response to Con A stimulation. The Lyt-1.2 subpopulation, helper cells, produces migration inhibition factor (MIF). The Lyt-2.2 subpopulation, suppressor cells, produces migration stimulation factor, (MStF). This is confirmed in the human system with tμ producing MIF and Tγ, MStF. When MIF-rich supernatants are added to lymphocyte suspensions undergoing transformation in response to phytohemagglutinin (PHA), transformation is significantly increased. This effect is blocked by the addition of 0.1 M l-fucose. In contrast MStF suppresses transformation in response to PHA, and also lowers background counts. It is suggested that MIF is a helper factor, and MStF, a suppressor factor.
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