Abstract
A link between ATP and SUR2A: A novel mechanism explaining cardioprotection at high altitude
Highlights
Medical Research Institute, Division of Cardiovascular and Diabetic Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK article info
High altitude is defined as living at an altitude of 2400 m or more above sea level
It is well established that prevalence of ischaemic heart disease is decreased in people living at high altitude and that the mortality from this disease is lower in this cohort
Summary
Medical Research Institute, Division of Cardiovascular and Diabetic Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK article info. International Journal of Cardiology 189 (2015) 73–76 A link between ATP and SUR2A: A novel mechanism explaining cardioprotection at high altitude☆ In our previous studies we have shown that sub-hypoxic drop of oxygen as well as mild hypoxia up-regulate SUR2A and confer cardioprotection [2,3].
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