Abstract
The experiments involving protein denaturation and refolding serve as the foundation for predicting the three-dimensional spatial structures of proteins based on their amino acid sequences. Despite significant progress in protein structure engineering, exemplified by AlphaFold2 and OmegaFold, there remains a gap in understanding the folding pathways of polypeptide chains leading to their final structures. We developed a lightweight tool for protein unfolding visualization called PUV whose graphics design is mainly implemented by OpenGL. PUV leverages principles from molecular biology and physics, and achieves rapid visual dynamics simulation of protein polypeptide chain unfolding through mechanical force and atom-level collision detection and elimination. After a series of experimental validations, we believe that this method can provide essential support for investigating protein folding mechanisms and pathways.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
