Abstract
Intaking molecular information from the external environment is essential for the normal functioning of artificial cells/molecular robots. Herein, we report the design and function of a membrane nanopore using a DNA origami square tube with a cross-section of 100 nm2. When the nanopore is added to a giant vesicle that mimics a cell membrane, the permeation of large external hydrophilic fluorescent molecules is observed. Furthermore, the addition of up to four ssDNA strands enables size-based selective transport of molecules. A controllable artificial nanopore should facilitate the communication between the vesicle components and their environment.
Highlights
ISSN 1359-7345 COMMUNICATION Min Luo, Ning Ye et al Unexpected aliovalent cation substitution between two NLO materials LiBa3Bi6(SeO3)7F11 and Ba3Bi6.5(SeO3)7F10.5O0.5
When the nanopore is added to a giant vesicle that mimics a cell membrane, the permeation of large external hydrophilic fluorescent molecules is observed
Three-dimensional DNA origami[10] was used to synthesize synthetic nanopores.9g–k The reported DNA origami nanopores allow the transport of differently sized molecules by expanding their pore size9g–i and further modifying the molecules inside the pores to enable size-based selective molecular transport.9k Artificial nanopores that allow the passage of certain chemical species through Giant unilamellar vesicles (GUVs) membranes are a realisation of molecular system compartments where chemical information can be exchanged, and they pass the information to macroscopic devices
Summary
ISSN 1359-7345 COMMUNICATION Min Luo, Ning Ye et al Unexpected aliovalent cation substitution between two NLO materials LiBa3Bi6(SeO3)7F11 and Ba3Bi6.5(SeO3)7F10.5O0.5. We report the design and function of a membrane nanopore using a DNA origami square tube with a cross-section of 100 nm[2]. Anchor-DNA is inserted into the lipid membrane owing to the hydrophobicity of cholesterol, and hybridisation with the artificial nanopores promotes the 2990 | Chem.
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