Abstract
Considering the global health threat posed by kidney disease burden, a search for new nephroprotective drugs from our local flora could prove a powerful strategy to respond to this health threat. In this study we investigated the antihyperuricemic and nephroprotective potential of RA-3, a plant-derived lanosteryl triterpene. The antihyperuricemic and nephroprotective effect of RA-3 was investigated using the adenine and gentamicin induced hyperuricemic and nephrotoxicity rat model. Following the induction of hyperuricemia and nephrotoxicity, the experimental model rats (Sprague Dawley) were orally administered with RA-3 at 50 and 100 mg/kg body weight, respectively, daily for 14 days. Treatment of the experimental rats with RA-3, especially at 100 mg/kg, effectively lowered the serum renal dysfunction (blood urea nitrogen and creatinine) and hyperuricemic (uric acid and xanthine oxidase) biomarkers. These were accompanied by increased antioxidant status with decrease in malondialdehyde content. A much improved histomorphological structure of the kidney tissues was also observed in the triterpene treated groups when compared to the model control group. It is evident that RA-3 possesses the antihyperuricemic and nephroprotective properties, which could be vital for prevention and amelioration of kidney disease.
Highlights
The recent massive hike of kidney disease on the global rankings of disease burden signals public health crisis [1]
Considering the the global global health health threat a search for for newnew Considering threat posed posed by bykidney kidneydisease diseaseburden, burden, a search nephroprotective drugs from our local flora could prove a powerful strategy to respond to this health nephroprotective drugs from our local flora could prove a powerful strategy to respond to this health threat.Potential
It was interesting to observe the significant decrease in serum levels of these biomarkers (UA, blood urea nitrogen (BUN), Cr) with improved histomorphology of the kidney tissues from the rats treated with RA-3 at both concentrations
Summary
The recent massive hike of kidney disease on the global rankings of disease burden signals public health crisis [1]. Kidney disease (nephropathy) is a product of multiple factors that inflict damage to nephron, renal parenchyma, and subsequent renal failure, if diagnosis and treatment are delayed [2]. Amongst various risk factors such as diabetes, hypertension, hyperuricemia, and infections, drug-induced nephrotoxicity is considered one of the significant contributors to both acute and chronic kidney disease [3]. This is attributable to increased exposure of the general population to a large number of prescribed and over-the-counter drugs as well as a variety of other ingested foodstuff and environmental intoxicants [4].
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