Abstract
PurposeTo build a knowledge‐based model of liver cancer for Auto‐Planning, a function in Pinnacle, which is used as an automated inverse intensity modulated radiation therapy (IMRT) planning system.Methods and MaterialsFifty Tomotherapy patients were enrolled to extract the dose–volume histograms (DVHs) information and construct the protocol for Auto‐Planning model. Twenty more patients were chosen additionally to test the model. Manual planning and automatic planning were performed blindly for all twenty test patients with the same machine and treatment planning system. The dose distributions of target and organs at risks (OARs), along with the working time for planning, were evaluated.ResultsStatistically significant results showed that automated plans performed better in target conformity index (CI) while mean target dose was 0.5 Gy higher than manual plans. The differences between target homogeneity indexes (HI) of the two methods were not statistically significant. Additionally, the doses of normal liver, left kidney, and small bowel were significantly reduced with automated plan. Particularly, mean dose and V15 of normal liver were 1.4 Gy and 40.5 cc lower with automated plans respectively. Mean doses of left kidney and small bowel were reduced with automated plans by 1.2 Gy and 2.1 Gy respectively. In contrast, working time was also significantly reduced with automated planning.ConclusionsAuto‐Planning shows availability and effectiveness in our knowledge‐based model for liver cancer.
Highlights
In recent decades, as a standard technique for external beam radiotherapy treatment (RT), intensity modulated radiation therapy (IMRT) has been widely considered as a safe and effective approach to the cure of hepatocellular carcinoma.[1,2,3,4] High quality radiotherapy treatment plan is essential to deliver a sufficiently high dose to the target while sparing healthy tissue
The target features were described by conformity index (CI), homogeneity indexes (HI) and mean dose of the planning tumor volume (PTV)
It could be considered that MA and AU plans performed no difference in HI
Summary
As a standard technique for external beam radiotherapy treatment (RT), IMRT has been widely considered as a safe and effective approach to the cure of hepatocellular carcinoma.[1,2,3,4] High quality radiotherapy treatment plan is essential to deliver a sufficiently high dose to the target while sparing healthy tissue. Obtaining high quality plans is a demanding task. There are no standard evaluating rules for a “good” plan, and the plan quality may extremely vary both between planners and treatment centers.[5,6,7] On the other hand, optimizing an IMRT plan is a time-consuming task. Several hours even days per case may be needed to achieve a clinically acceptable plan.[8,9] In addition, the complex of planning grows rapidly as the number of OARs increases
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