Abstract
A nonlinear compartmental model of the clearance kinetics of amosite asbestos fibers in the alveolar region of the rat lung at the dust overload condition is proposed, in which the clearance rate coefficient is dependent on the lung burden. Using this model together with a deposition model which we developed previously, we calculated the accumulation of amosite asbestos fibers in the rat lung during chronic exposure. The effects of breathing condition, exposure-concentration, and post-exposure period on the lung burden were examined in the model. Comparisons are made between the calculated lung burden and existing experimental data.
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