Abstract
We have inferred, from computer simulations of clonal growth data, mean cell cycle time (Tc) for putative subpopulations of fibroblastic cells having unique replicative potentials. The growth kinetics of chick embryo fibroblast clones can be accounted for if it is assumed that: (1) there is a transient, and rather substantial, decline in mean Tc (from 34 to 12 hr) immediately following the commitment of a 'stem' cell daughter to a limited replicative lifespan; (2) the mean Tc increases progressively (from 12 to 48 hr) as 'committed' cells exhaust their remaining replicative potential; and (3) the daughters of committed cells may occasionally become abruptly post-mitotic.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
