Abstract
Darling’s disease has diverse presentations and raises several laboratory diagnostic and safety issues. This case report discusses the laboratory work-up of a renal transplant patient from New Caledonia, transferred with prolonged respiratory illness progressing to respiratory failure, and subsequent multi-organ failure. Disseminated histoplasmosis was diagnosed, with Histoplasma capsulatum isolated from bronchoalveolar lavage and evidence of fungaemia in blood film examination. H. capsulatum is a dimorphic fungus with a wide spectrum of clinical disease manifestations. Strict adherence to laboratory protocols and risk assessment minimises risk of laboratory-related exposure and acquisition of disease.
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