Abstract
A Key to Genome Maze in 3D
Highlights
A recent paper published by Tang et al in the last issue of Cell in 2015 represents a substantial progress in addressing the aforementioned challenges [12]
Since CTCF recognizes and binds to an asymmetric DNA motif with core sequence CCCTC [13], CTCF binding is usually considered to be directional. In this newly-generated CTCF-mediated chromatin contact map, a surprisingly high portion of interactions were found to be so called ‘‘tandem loops”, which are mediated by CTCF dimers with the motifs facing the same direction in the genome
The two different looping types proposed may be important for cells to modularize the spatial organization of genome, because the convergent loops, which define the so-called CTCF-mediated chromatin contact domains (CCDs), are more likely to be found between distal genome loci, and largely consistent with previously-reported TADs, whereas tandem loops are evenly distributed within CCDs
Summary
A recent paper published by Tang et al in the last issue of Cell in 2015 represents a substantial progress in addressing the aforementioned challenges [12]. In this newly-generated CTCF-mediated chromatin contact map, a surprisingly high portion of interactions were found to be so called ‘‘tandem loops”, which are mediated by CTCF dimers with the motifs facing the same direction in the genome.
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