Abstract
A key enzyme upregulating collagen production by scleroderma fibroblasts
Highlights
Systemic sclerosis (SSc) is a fibroproliferative autoimmune disease characterized by the excessive production and deposition of collagen in skin and internal organs
The aim of the present study was to examine the possible role of protein kinase C-d (PKC-d) in the upregulation collagen gene expression in SSc dermal fibroblasts
This study identified a 129-bp promoter region of the type I collagen gene encompassing nucleotides -804 to -675 which was responsive to the transcriptional inhibition by rottlerin and dominant-negative PKC-d expression
Summary
Systemic sclerosis (SSc) is a fibroproliferative autoimmune disease characterized by the excessive production and deposition of collagen in skin and internal organs. A key enzyme upregulating collagen production by scleroderma fibroblasts Hideto Kameda Tsutomu Takeuchi,Aff[1]
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