Abstract
Drug-induced liver injury can develop depending on the drug itself, its metabolites or the host immune system. Hydroxychloroquine (HCQ) is used prevalently in the treatment of rheumatological diseases. Severe liver toxicities associated with HCQ have been rarely reported in the literature. We present the case of a 36-year-old female patient who was using HCQ due to adult Still's disease whose initial values were normal but arrived 3 weeks later with severely high liver enzyme and bilirubin levels. The diagnosis of acute severe liver disease due to HCQ use was made by eliminating other causes and conducting a liver biopsy. The patient recovered completely with steroid therapy. It should be kept in mind that HCQ, which was prevalently used worldwide at the beginning of the coronavirus disease-2019 pandemic, can lead to severe liver disease in rare cases.
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