Abstract
Objectives: Previous reports on the follicle stimulating hormone receptor (FSHR) and choriogonadotrophic/luteinizing hormone receptor (CG/LHR), which belong to the glycoproteinhormone receptor (GPHR) family, suggest that the extracellular loop (ECL) 3 could be a key domain for ligand binding and intramolecular receptor signaling. In contrast to ECLs 1 and 2 of GPHRs, the ECL3 displays high sequence homology, particularly in the central portion of the loop. Therefore, we opted to identify amino acids with functional importance within ECL3 of the thyroid stimulating hormone receptor (TSHR).
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