Abstract
By dint of unique physical/chemical properties and bio-compatibility, graphene can work as a building block for a SERS substrate and open up a unique platform for tumor cells detection with high sensitivity. Herein we demonstrate a facile system with highly enhanced surface enhanced Raman spectroscopy of graphene (G-SERS). The system consists of a reduced graphene oxide (rGO) sandwiched by silver and gold nanostructures. Due to the ultrasmall thickness of rGO, the inter-coupling between Ag and Au nanoparticles is precisely controlled and the local field enhancement has been improved to more than 70 times. Associated with the unique chemical mechanism of rGO, the hybrid system has been utilized to identify tumor cells without using any biomarkers. We believe this research will be important for the applications of rGO in cancer screening.
Highlights
RGO@Au) is designed and the schematic is shown in Fig. 1
The graphene oxide (GO) solution with concentration of ~6 mg mL−1 is spin-coated on the as-prepared substrate of Au@Si, followed by high-temperature annealing in argon gas to obtain reduced graphene oxide (rGO)
We further extend our research for a sandwich structure of Ag@rGO@Au to realize coupling between two localized fields to achieve even higher hot spot for Raman enhancement
Summary
The highest enhancement factor defined as I’/I0 is obtained for Ag layer with thickness of 3 nm with a value of 10 as shown in green dashed line, with I’ and I0 denoted as the Raman signal intensity with and without Ag film on top of rGO, respectively[2].
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