Abstract
AbstractIn this article, a hybrid system of hydrogel/frog egg‐like microspheres (H‐FMS) formed by the combination of coaxial electrostatic spraying and freeze‐drying was introduced for enhancing wound healing efficiency through the sustained release ofRana chensinensisskin peptides (RCSPs). The porous PVA/gelatin hydrogel were obtained and frog egg‐like microspheres (FMS) of sodium alginate (SA), shaping uniform and smooth, were embedded into hydrogel. Based on PVA/gelatin hydrogel, the FMS addition increased the water absorption of hydrogel to 1,105%. RCSPs were more effectively encapsulated into FMS than solid microspheres (MS). Not only does the H‐FMS act as good “depots” for sustained release of RCSPs over 9 days, without exhibiting obvious burst release, but also show good biocompatibility in vitro. In vivo studies on wound healing as well as the histology of fibroblasts, re‐epithelialization, inflammation, and hair follicles indicated that the structure of H‐FMS released RCSPs continuously and promoted wound healing in rats significantly.
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