Abstract
Cancer is among the leading causes of death worldwide, thus there is a constant demand for new solutions, which may increase the effectiveness of anti-cancer therapies. We have designed and successfully obtained a novel, bifunctional, hybrid system composed of colloidally stabilized superparamagnetic iron oxide nanoparticles (SPION) and curcumin containing water-soluble conjugate with potential application in anticancer hyperthermia and as nanocarriers of curcumin. The obtained nanoparticulate system was thoroughly studied in respect to the size, morphology, surface charge, magnetic properties as well as some biological functions. The results revealed that the obtained nanoparticles, ca. 50 nm in diameter, were the agglomerates of primary particles with the magnetic, iron oxide cores of ca. 13 nm, separated by a thin layer of the applied cationic derivative of chitosan. These agglomerates were further coated with a thin layer of the sodium alginate conjugate of curcumin and the presence of both polymers was confirmed using thermogravimetry. The system was also proven to be applicable in magnetic hyperthermia induced by the oscillating magnetic field. A high specific absorption rate (SAR) of 280 [W/g] was registered. The nanoparticles were shown to be effectively uptaken by model cells. They were found also to be nontoxic in the therapeutically relevant concentration in in vitro studies. The obtained results indicate the high application potential of the new hybrid system in combination of magnetic hyperthermia with delivery of curcumin active agent.
Highlights
Superparamagnetic iron oxide nanoparticles (SPION) are intensely studied due to their broad potential applications in medicine
N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (CCh), was obtained and characterized in accordance with the procedures described in the previous work [15]; its modification degree with trimethylammonium groups was indicated to be
The image of superparamagnetic iron oxide nanoparticles (SPION)-CCh/AA-Cur shows formed by magnetic coresbycoated with acores polymeric
Summary
Superparamagnetic iron oxide nanoparticles (SPION) are intensely studied due to their broad potential applications in medicine. Thanks to their superparamagnetic properties, SPION proved. SPION have gained attention due to their ability to induce magnetic hyperthermia (MHT) [4]. When an external alternating magnetic field of specific frequency is applied, it causes SPION to heat. MHT allows for the local treatment of tumors with only moderate side effects, and may be considered well tolerated in comparison to other available therapies [6,7], because tumors are more susceptible to heat compared with normal tissue. Safety of the treatment depends on the favorable biodistribution of the nanoparticles with their increased concentration in tumor tissue
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