A HYBRID OF GENETIC ALGORITHM AND SUPPORT VECTOR MACHINE FOR FEATURES SELECTION AND CLASSIFICATION OF GENE EXPRESSION MICROARRAY

Abstract

Constantly improving gene expression technology offer the ability to measure the expression levels of thousand of genes in parallel. Gene expression data is expected to significantly aid in the development of efficient cancer diagnosis and classification platforms. Key issue that needs to be addressed is the selection of small number of genes that contribute to a disease from the thousands of genes measured on microarrays that are inherently noisy. This work deals with finding a small subset of informative genes from gene expression microarray data which maximise the classification accuracy. This paper introduces a new algorithm of hybrid Genetic Algorithm and Support Vector Machine for genes selection and classification task. We show that the classification accuracy of the proposed algorithm is superior to a number of current state-of-the-art methods of two widely used benchmark datasets. The informative genes from the best subset are validated and verified by comparing them with the biological results produced from biologist and computer scientist researches in order to explore the biological plausibility.