Abstract
The rheological behavioral changes that occurred during the synthesis of an interpolyelectrolyte complex (IPEC) of methacrylate copolymer and sodium carboxymethylcellulose were assessed. These changes were compared with the rheological behavior of the individual polymers employing basic viscosity, yield stress, stress sweep, frequency sweep, temperature ramp as well as creep and recovery testing. The rheological studies demonstrated that the end-product of the complexation of low viscous methacrylate copolymer and entangled solution of sodium carboxymethylcellulose generated a polymer, which exhibited a solid-like behavior with a three-dimensional network. Additionally, the rheological profile of the sodium carboxymethylcellulose and methacrylate copolymer with respect to the effect of various concentrations of acetic acid on the synthesis of the IPEC was elucidated using molecular mechanics energy relationships (MMER) by exploring the spatial disposition of carboxymethylcellulose and methacrylate copolymer with respect to each other and acetic acid. The computational results corroborated well with the experimental in vitro drug release data. Results have shown that the IPEC may be suitable polymeric material for achieving controlled zero-order drug delivery.
Highlights
A Hybrid Methacrylate-Sodium CarboxymethylcelluloseNdidi Chinyelu Ngwuluka 1, Yahya Essop Choonara 1, Pradeep Kumar 1, Girish Modi 2, Lisa Claire du Toit 1, and Viness Pillay 1,*
Science and technology has resulted in various nanostructured materials to be rapidly developed, the contributions of polymer-based materials still have a crucial role, especially rheological characterization of polymer blends or modified polymers
For polyelectrolyte such as sodium carboxymethylcellulose (NaCMC), the conformation and rheological behavior exhibited is influenced by its ionization grade, which depends on the pH and ionic strength [4]
Summary
Ndidi Chinyelu Ngwuluka 1, Yahya Essop Choonara 1, Pradeep Kumar 1, Girish Modi 2, Lisa Claire du Toit 1, and Viness Pillay 1,*. Faculty of Health Sciences, Division of Neurosciences, Department of Neurology, University of the. Received: 4 July 2013; in revised form: 13 August 2013 / Accepted: 16 August 2013 /
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