Abstract
Gastritis is an inflammation of the gastric mucosa. In this study, we investigated the efficacy of a medical device, Esoxx®, based on hyaluronic acid and chondroitin sulfate on gastritis-related upper abdominal pain/discomfort and endoscopic features. Fifty patients, affected by gastritis, were randomised to receive the medical device or placebo. The primary endpoint was the medical device efficacy on upper abdominal pain/discomfort associated with gastritis and measured by Visual Analogue Scale (VAS). The secondary endpoints were the efficacy of the medical device on gastritis-related mucosal erosions, blood oozing, and hyperemia (redness)/edema, as assessed by endoscopy, and the patients’ rating of their compliance with the treatments. A significant reduction in VAS pain was observed in the treatment group after a 5-week treatment, if compared with placebo (p < 0.001). In summary, administration of a medical device, based on hyaluronic acid and chondroitin sulfate, improves gastritis-related upper abdominal pain/discomfort and decreases mucosal erosions, blood oozing, and hyperemia (redness)/edema at 5-week follow-up in patients affected by gastritis.
Highlights
Gastritis is commonly defined as a histologically confirmed inflammation of the gastric mucosa and affects up to 50% of the population worldwide [1]
hyaluronic acid (HA) interacts with several cell surface receptors such as cluster determinant 44 (CD44) and the receptor for hyaluronate-mediated motility (RHAMM), which have been associated with malignant transformation of gastric mucosa, their expression has been reported in non-malignant mucosa [13,14,15]
We hypothesized that HA and chondroitin sulfate (CS) would steadily coat the epithelial surface of the gastric mucosa stimulating the healing process in a subset of patients affected by gastritis characterized by upper abdominal pain/discomfort and mucosal erosions, blood oozing, and hyperemia/edema
Summary
Gastritis is commonly defined as a histologically confirmed inflammation of the gastric mucosa and affects up to 50% of the population worldwide [1]. CS molecular structure was identified by Babkin and Komarov [9] as an effective inhibitor of pepsin-induced damage to the gastroduodenal mucosa. To date, no clinical study has shown an effectiveness of a compound based on HA and CS on gastritis-related upper abdominal pain/discomfort and endoscopic features. We hypothesized that HA and CS would steadily coat the epithelial surface of the gastric mucosa stimulating the healing process in a subset of patients affected by gastritis characterized by upper abdominal pain/discomfort and mucosal erosions, blood oozing, and hyperemia (redness)/edema
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