Abstract
Evidence is adduced to show that labile tissue factors obtained from human chorion and cancer interact with a component found in human serum to give a thromboplastic product capable of promoting the conversion of prothrombin to thrombin. The serum component differs from prothrombin in its chromatographic properties and in thermolability, as well as in its biological behaviour. The relevance of this finding to the formation of fibrin by human cancers during their growth is discussed.
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