Abstract
Intra-abdominal hypertension may have catastrophic effects in the critically ill, but its pathophysiology is only partially understood. In a human model of intra-abdominal hypertension of 12 mmHg, 50 living kidney donors were randomized between hand-assisted laparoscopic nephrectomy and open nephrectomy. In the laparoscopic group intra-abdominal hypertension of 12 mmHg was induced. Markers of inflammation and renal function were obtained in both groups peri-operatively. Slightly elevated intra-abdominal pressure leads to increased acute CRP, IL-6 and plasma NGAL.
Highlights
Intra-abdominal hypertension (IAH) may have catastrophic effects on critically ill patients, but its pathophysiology is only partially understood [1]
50 living kidney donors were randomly assigned between hand-assisted laparoscopy by a transperitoneal approach and open nephrectomy by a retroperitoneal approach [4]
In this human model of IAH, a carbon dioxide pneumo-peritoneum of 12 mm Hg was induced during the procedure in the laparoscopic group
Summary
Intra-abdominal hypertension (IAH) may have catastrophic effects on critically ill patients, but its pathophysiology is only partially understood [1]. We analyzed markers of inflammation and renal function in a prospective randomized clinical trial. 50 living kidney donors were randomly assigned between hand-assisted laparoscopy by a transperitoneal approach and open nephrectomy by a retroperitoneal approach [4]. In this human model of IAH, a carbon dioxide pneumo-peritoneum of 12 mm Hg was induced during the procedure in the laparoscopic group.
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