Abstract
Host-induced changes of HVJ in hemolytic activity and in growth characteristics in mouse lung cells were investigated. HVJ grown in the allantoic cavity of the chick embryo is hemolytic, but the virus loses this property after a single passage in the mouse lung or after a single growth cycle in cultivated mouse lung cells. This nonhemolytic virus becomes hemolytic after a single chick embryo passage. Similar changes in virus growth characteristics were also observed. When HVJ was adapted to growth in monolayers of mouse lung cells, virus was produced within 24 hours of infection, but cytopathic effects were delayed, often for several days. After one passage in the chick embryo, however, this virus reproduced in the tissue culture with concomitant destruction of the cells. After a single passage in tissue culture the cytopathic virus returned to the noncytopathic condition.
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